Receptor paratiroidnog hormona 2
| Receptor paratiroidnog hormona 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PTH2R; PTHR2 | ||||||||||
| Vanjski ID | OMIM: 601469 MGI: 2180917 HomoloGene: 3701 IUPHAR: PTH2 GeneCards: PTH2R Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5746 | 213527 | |||||||||
| Ensembl | ENSG00000144407 | ENSMUSG00000025946 | |||||||||
| UniProt | P49190 | Q91V95 | |||||||||
| RefSeq (mRNA) | NM_005048.2 | NM_139270.2 | |||||||||
| RefSeq (protein) | NP_005039.1 | NP_644676.1 | |||||||||
| Lokacija (UCSC) |
Chr 2: 209.22 - 209.72 Mb |
Chr 1: 65.33 - 65.44 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Parathyroid hormone 2 receptor je protein koji je kod ljudi kodiran PTH2R genom[1]
Funkcija
[уреди | уреди извор]Ovaj protein je član familije 2 G protein spregnutih receptora. On je receptor za paratiroidni hormon (PTH). Ovaj receptor je selektiviji u prepoznavanju liganda i ima specifičniju tkivnu distribuciju u poređenju sa receptorom paratiroidnog hormona 2 (PTH1R). On se aktivira samo posredstvom PTH, a ne i PTHLH. on je posebno zastupljen u mozgu i pankreasu.[1]
Reference
[уреди | уреди извор]Literatura
[уреди | уреди извор]- Usdin TB, Gruber C, Bonner TI (1995). „Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.”. J. Biol. Chem. 270 (26): 15455—8. PMID 7797535. doi:10.1074/jbc.270.26.15455.
- Usdin TB, Modi W, Bonner TI (1997). „Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.”. Genomics. 37 (1): 140—1. PMID 8921382. doi:10.1006/geno.1996.0532.
- Clark JA, Bonner TI, Kim AS, Usdin TB (1998). „Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.”. Mol. Endocrinol. 12 (2): 193—206. PMID 9482662. doi:10.1210/me.12.2.193.
- Hoare SR, Clark JA, Usdin TB (2000). „Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.”. J. Biol. Chem. 275 (35): 27274—83. PMID 10854439. doi:10.1074/jbc.M003910200.
- John MR; Arai M; Rubin DA; et al. (2002). „Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.”. Endocrinology. 143 (3): 1047—57. PMID 11861531. doi:10.1210/en.143.3.1047.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Seeliger S; Hausberg M; Eue I; et al. (2003). „The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.”. Clin. Nephrol. 59 (6): 429—35. PMID 12834174.
- Bisello A; Manen D; Pierroz DD; et al. (2004). „Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.”. Mol. Endocrinol. 18 (6): 1486—98. PMID 14988434. doi:10.1210/me.2003-0487.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.”. FEBS Lett. 579 (3): 803—7. PMID 15670850. doi:10.1016/j.febslet.2004.12.056.
Vidi još
[уреди | уреди извор]Spoljašnje veze
[уреди | уреди извор]- „Parathyroid Hormone Receptors: PTH2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
- Receptor,+Parathyroid+Hormone,+Type+2 на US National Library of Medicine Medical Subject Headings (MeSH)